Synthesis of Novel Selenides Bearing Benzenesulfonamide Moieties as Carbonic Anhydrase I, II, IV, VII, and IX Inhibitors

Andrea Angeli; Damiano Tanini; Antonella Capperucci; Claudiu T Supuran

doi:10.1021/acsmedchemlett.7b00387

Synthesis of Novel Selenides Bearing Benzenesulfonamide Moieties as Carbonic Anhydrase I, II, IV, VII, and IX Inhibitors

ACS Med Chem Lett. 2017 Nov 7;8(12):1213-1217. doi: 10.1021/acsmedchemlett.7b00387. eCollection 2017 Dec 14.

Authors

Andrea Angeli¹, Damiano Tanini², Antonella Capperucci², Claudiu T Supuran¹

Affiliations

¹ Department of University of Florence, NEUROFARBA Dept., Sezione di Scienze Farmaceutiche, Via Ugo Schiff 6, 50019 Sesto Fiorentino (Florence), Italy.
² Department of University of Florence, Department of Chemistry "Ugo Schiff″, Via della Lastruccia 13, I-50019 Sesto Fiorentino, Italy.

Abstract

A series of novel selenides bearing benzenesulfonamide moieties was synthesized and investigated for the inhibition of five human (h) isoforms of zinc enzyme carbonic anhydrase (CA, EC 4.2.1.1), hCA I, II, IV, VII, and IX. These enzymes are involved in a variety of diseases, including glaucoma, retinitis pigmentosa, epilepsy, arthritis, and tumors. The investigated compounds showed potent inhibitory action against hCA II, VII, and IX, in the low nanomolar range, thus making them of interest for the development of isoform-selective inhibitors and as candidates for biomedical applications.